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When the crite-rion was defined as clouding of consciousness or inatten-tion, the sensitivity and specificity of DSM-IV, DSM-III,and ICD-10 criteria were 100% and 71%; 96% and 91%;and 61% and 91%, respectively, with similar results withor without dementia present. Interestingly, the histone deacetylase SIRT1 canalso localizes into the PML-NBs and reduce the acetylation of p53 at Lys382 andthereby antagonize the induction of p53 activity [216, 217]

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